Madrigal Pharmaceuticals, Inc.

1. 01

   Set a 52-week low on 4 Nov 2026

   Closed at $400.43 on 4 Nov 2026: 34.9% below the 52-week high of $615.00 (24 Dec 2025) and 13.3% above the low of $353.54 (4 Nov 2026).

   Daily price bars, split-adjusted · as of 4 Nov 2026

2. 02

   Behind SPY and its sector fund XLV over 1 year

   1 month: −19.3% (SPY −1.6%, XLV +13.5%). 3 months: −22.1% (SPY −0.4%, XLV +15.5%). 1 year: −9.9% (SPY +13.6%, XLV +30.7%). Price change to the 4 Nov 2026 close; dividends excluded.

   Daily closes, split-adjusted: MDGL, SPY and XLV · as of 4 Nov 2026

3. 03

   Volume 6.6× its 30-session average on 4 Nov 2026

   4 Nov 2026 volume of 2.3M shares was 6.6× the average of the 30 sessions before it (349.7K), as the price rose 1.0%. SPY traded 1.5× its own average that session.

   Daily volume against a 30-session baseline · as of 4 Nov 2026

4. 04

   Below its 50- and 200-day averages

   The 4 Nov 2026 close of $400.43 was 18.7% below its 50-day average ($492.40) and 19.7% below its 200-day average ($498.57). It has closed below the 200-day for 27 sessions, since 29 Sep 2026. The 50-day average crossed below the 200-day on 30 Oct 2026, 3 sessions ago.

   Daily closes, split-adjusted; 50- and 200-session simple averages · as of 4 Nov 2026

5. 05

   7.2 days to cover short interest

   2.2M shares were sold short at the 15 Oct 2026 settlement, 9.5% of the 23.1M shares outstanding; covering them would take 7.2 days of average volume. Short interest is reported twice a month, on a lag.

   Exchange short-interest filing · as of 15 Oct 2026

At the 4 Nov 2026 close